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Ritonavir or lopinavir/ritonavir tremendously increase plasma concentrations of oxycodone in healthful human volunteers on account of inhibition of CYP3A4 and CYP2D6.[58] Rifampicin drastically decreases plasma concentrations of oxycodone resulting from solid induction of CYP3A4.For appropriate individuals who endure with Long-term non-malignant pa